The 12th Korea-Singapore Joint Workshop on Bioinformatics and Natural Language Processing was held in KAIST and Gyeryongsan Natural History Museum, Daejeon, Korea on Sept. 22-23, 2016. We had five invited presentations given by Prof. Limsoon Wong (NUS, Singapore), Prof. Kwang-Hyun Cho (KAIST, Korea), Dr. See-Kiong Ng (I2R, Singapore), Dr. Jie Zheng (NTU, Singapore), and Dr. Wei Lu (SUTD, Singapore).